Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05REP
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| Drug Name |
Pyridine-carboximide derivative 2
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| Synonyms |
PMID25470667-Compound-Figure5-6
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| Drug Type |
Small molecular drug
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| Company |
MERCK SHARP & DOHME CORP. TING, Pauline, C. ASLANIAN, Robert CAO, Jianhua KIM, David ZORN, Nicolas
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| Structure |
 |
Download2D MOL |
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| Formula |
C29H27N3O5
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| Canonical SMILES |
C1CN(CCC1COC2=CC=CC(=C2)C(=O)O)C3=NC=C(C=C3)NC(=O)C4=CC=C(O4)C5=CC=CC=C5
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| InChI |
1S/C29H27N3O5/c33-28(26-11-10-25(37-26)21-5-2-1-3-6-21)31-23-9-12-27(30-18-23)32-15-13-20(14-16-32)19-36-24-8-4-7-22(17-24)29(34)35/h1-12,17-18,20H,13-16,19H2,(H,31,33)(H,34,35)
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| InChIKey |
FQDLXNVBCMMHLG-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Diacylglycerol acyltransferase 1 (DGAT1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Diacylglycerol acyltransferase 1 (DGAT1) | Target's Patent Info | [1] | |
| BioCyc | Triacylglycerol biosynthesis | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Retinol metabolism | ||||
| Metabolic pathways | ||||
| Fat digestion and absorption | ||||
| Pathwhiz Pathway | Retinol Metabolism | |||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Triglyceride Biosynthesis | ||||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Statin Pathway | ||||
| Triacylglyceride Synthesis | ||||
| Glycerophospholipid biosynthesis | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. | |||
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