Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05QTX
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| Former ID |
DIB020626
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| Drug Name |
Org27569
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| Synonyms |
Org 27569
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C24H28ClN3O
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| Canonical SMILES |
CCC1=C(NC2=C1C=C(C=C2)Cl)C(=O)NCCC3=CC=C(C=C3)N4CCCCC4
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| InChI |
1S/C24H28ClN3O/c1-2-20-21-16-18(25)8-11-22(21)27-23(20)24(29)26-13-12-17-6-9-19(10-7-17)28-14-4-3-5-15-28/h6-11,16,27H,2-5,12-15H2,1H3,(H,26,29)
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| InChIKey |
AHFZDNYNXFMRFQ-UHFFFAOYSA-N
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| CAS Number |
CAS 868273-06-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
90341443, 104253193, 120140535, 124757323, 125164127, 135698815, 136348244, 136367539, 152258523, 160647358, 160698730, 160869022, 162011818, 162038062, 162205096, 163122471, 163564970, 174531084, 176238999, 178233167, 185972545, 188919889, 204362481, 215783629, 223366181, 223601165, 242059896, 246776465, 249797656, 252079880, 252156902, 252215959
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Modulator (allosteric modulator) | [2] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | ||||
| Panther Pathway | Endogenous cannabinoid signaling | |||
| Pathway Interaction Database | N-cadherin signaling events | |||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| BDNF signaling pathway | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569. J Biol Chem. 2012 Sep 28;287(40):33873-82. | |||
| REF 2 | Indole-2-carboxamides as allosteric modulators of the cannabinoid CB receptor. J Med Chem. 2012 Jun 14;55(11):5627-31. | |||
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