Drug Information
Drug General Information | Top | |||
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Drug ID |
D05LTJ
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Former ID |
DCL001062
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Drug Name |
ISIS 325568
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Synonyms |
BDBM231666; N-(2-(1H-indol-3-yl)ethyl)-3-(3-thiazol-2-ylureido)benzenesulfonamide (1b)
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Drug Type |
Antisense drug
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Indication | Type-2 diabetes [ICD-11: 5A11; ICD-9: 250] | Phase 1 | [1] | |
Therapeutic Class |
Antisense
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Company |
Licensed to Ortho-McNeil, Inc.
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PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Glucagon receptor messenger RNA (GCGR mRNA) | Target Info | . | [2] |
Reactome | Glucagon signaling in metabolic regulation | |||
G alpha (q) signalling events | ||||
G alpha (s) signalling events | ||||
Glucagon-type ligand receptors |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT00519727) Safety Study of ISIS 325568 in Healthy Volunteers. U.S. National Institutes of Health. | |||
REF 2 | Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. |
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