Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05FRX
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| Former ID |
DNC005482
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| Drug Name |
(3,5-Dibromo-4-hexyloxy-phenyl)-acetic acid
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| Synonyms |
CHEMBL192639; SCHEMBL4900725; BDBM18902; ZINC13643202; 3,5-Dibromo-4-alkoxyphenylalkanoic Acid, 9e; 2-[3,5-dibromo-4-(hexyloxy)phenyl]acetic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H18Br2O3
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| Canonical SMILES |
CCCCCCOC1=C(C=C(C=C1Br)CC(=O)O)Br
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| InChI |
1S/C14H18Br2O3/c1-2-3-4-5-6-19-14-11(15)7-10(8-12(14)16)9-13(17)18/h7-8H,2-6,9H2,1H3,(H,17,18)
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| InChIKey |
VJKVJESSSPWLJY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thyroid hormone receptor alpha (THRA) | Target Info | Inhibitor | [1] |
| Thyroid hormone receptor beta (THRB) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Thyroid hormone signaling pathway | ||||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Hematopoietic Stem Cell Differentiation | ||||
| Nuclear Receptors | ||||
| Endochondral Ossification | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. J Med Chem. 2005 May 5;48(9):3114-7. | |||
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