Drug Information
Drug General Information | Top | |||
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Drug ID |
D05FQD
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Former ID |
DNCL002685
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Drug Name |
Metaiodobenzylguanidine I-131
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Synonyms |
Azedra (TN)
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Drug Type |
Small molecular drug
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Indication | Neuroblastoma [ICD-11: 2D11.2] | Phase 2 | [1] | |
Neuroendocrine cancer [ICD-11: 2B72.1; ICD-9: 209] | Phase 2 | [2] | ||
Pheochromocytoma [ICD-11: 5A75; ICD-10: E27.5] | Application submitted | [3] | ||
Company |
Molecular Insights Pharmaceuticals
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Structure |
Download2D MOL |
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Formula |
C8H10IN3
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Canonical SMILES |
C1=CC(=CC(=C1)I)CN=C(N)N
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InChI |
1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)/i9+4
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InChIKey |
PDWUPXJEEYOOTR-JRGAVVOBSA-N
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CAS Number |
CAS 77679-27-7
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:135997
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Target and Pathway | Top | |||
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Target(s) | Norepinephrine transporter (NET) | Target Info | Modulator | [4] |
Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
WikiPathways | Monoamine Transport | |||
NRF2 pathway | ||||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004852) | |||
REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 4 | Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clin Cancer Res. 2014 Apr 15;20(8):2182-91. |
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