Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05FBZ
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| Former ID |
DIB015155
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| Drug Name |
CPHPC
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| Synonyms |
Amyloid beta inhibitor; SAP binding inhibitor, Roche; Serum amyloid P binding inhibitor, Roche; Ro-63-8695
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| Drug Type |
Small molecular drug
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| Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Phase 1/2 | [1], [2] | |
| Company |
F Hoffmann-La Roche Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C16H24N2O6
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| Canonical SMILES |
C1CC(N(C1)C(=O)CCCCC(=O)N2CCCC2C(=O)O)C(=O)O
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| InChI |
1S/C16H24N2O6/c19-13(17-9-3-5-11(17)15(21)22)7-1-2-8-14(20)18-10-4-6-12(18)16(23)24/h11-12H,1-10H2,(H,21,22)(H,23,24)/t11-,12-/m1/s1
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| InChIKey |
HZLAWYIBLZNRFZ-VXGBXAGGSA-N
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| CAS Number |
CAS 224624-80-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Serum amyloid P-component (APCS) | Target Info | Modulator | [3] |
| Reactome | Amyloid formation | |||
| WikiPathways | Human Complement System | |||
| Amyloids | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8256). | |||
| REF 2 | ClinicalTrials.gov (NCT02425241) Depletion of Serum Amyloid P Component to Enhance the Immune Response to DNA Vaccination. U.S. National Institutes of Health. | |||
| REF 3 | Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).Acta Crystallogr D Biol Crystallogr.2014 Aug;70(Pt 8):2232-40. | |||
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