Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05ENJ
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| Former ID |
DIB009130
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| Drug Name |
Fasitibant chloride
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| Synonyms |
MEN-16132; Bradykinin B2 antagonist (inflammation), Menarini; MEN-11270 analogs, Menarini
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| Drug Type |
Small molecular drug
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| Indication | Osteoarthritis [ICD-11: FA00-FA05; ICD-9: 715] | Phase 2 | [1] | |
| Company |
The Menarini Group
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| Structure |
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Download2D MOL
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| Formula |
C36H49Cl3N6O6S
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| Canonical SMILES |
CC1=CC(=NC2=C1C=CC=C2OCC3=C(C=CC(=C3Cl)S(=O)(=O)NC4(CCOCC4)C(=O)N5CCN(CC5)C(=O)C(CCC[N+](C)(C)C)N)Cl)C.[Cl-]
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| InChI |
1S/C36H49Cl2N6O6S.ClH/c1-24-22-25(2)40-33-26(24)8-6-10-30(33)50-23-27-28(37)11-12-31(32(27)38)51(47,48)41-36(13-20-49-21-14-36)35(46)43-17-15-42(16-18-43)34(45)29(39)9-7-19-44(3,4)5;/h6,8,10-12,22,29,41H,7,9,13-21,23,39H2,1-5H3;1H/q+1;/p-1/t29-;/m0./s1
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| InChIKey |
ZNHJDJYKDVGQSH-JMAPEOGHSA-M
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01091116) A Locally Injected Bradykinin Antagonist for TReatment of OSteoarthritiS. U.S. National Institutes of Health. | |||
| REF 2 | Fasitibant chloride, a kinin B receptor antagonist, and dexamethasone interact to inhibit carrageenan-induced inflammatory arthritis in rats. Br J Pharmacol. 2012 Jun;166(4):1403-10. | |||
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