Drug Information
Drug General Information | Top | |||
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Drug ID |
D05EHX
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Drug Name |
US9422240, 1-282
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Synonyms |
SCHEMBL16762172; CHEMBL3896281; BDBM242546; US9422240, 1-282
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C21H19FN2O6
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Canonical SMILES |
C1CN(C(=O)C(=C1O)C(=O)NCC(=O)O)CC2=CC=C(C=C2)OC3=CC=CC=C3F
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InChI |
1S/C21H19FN2O6/c22-15-3-1-2-4-17(15)30-14-7-5-13(6-8-14)12-24-10-9-16(25)19(21(24)29)20(28)23-11-18(26)27/h1-8,25H,9-12H2,(H,23,28)(H,26,27)
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InChIKey |
FFAFLVNMXIWUFY-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
KEGG Pathway | HIF-1 signaling pathway | |||
Pathways in cancer | ||||
Renal cell carcinoma | ||||
Panther Pathway | Hypoxia response via HIF activation | |||
Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
HIF-1-alpha transcription factor network | ||||
Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
References | Top | |||
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REF 1 | Partially saturated nitrogen-containing heterocyclic compound. US9422240. |
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