Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05DNA
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| Former ID |
DIB007236
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| Drug Name |
FR-183998
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| Synonyms |
FR-183998; AC1OCFC6; SCHEMBL6134503; 3-N-(diaminomethylidene)-5-(2,5-dichlorothiophen-3-yl)-1-N-(2-dimethylaminoethyl)benzene-1,3-dicarboxamide dihydrochloride; 3-(2,5-dichlorothiophen-3-yl)-N-[2-(dimethylamino)ethyl]-5-guanidinocarbonylbenzamide dihydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Terminated | [1] | |
| Company |
Fujisawa Pharmaceutical Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C17H21Cl4N5O2S
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| Canonical SMILES |
CN(C)CCNC(=O)C1=CC(=CC(=C1)C2=C(SC(=C2)Cl)Cl)C(=O)N=C(N)N.Cl.Cl
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| InChI |
1S/C17H19Cl2N5O2S.2ClH/c1-24(2)4-3-22-15(25)10-5-9(12-8-13(18)27-14(12)19)6-11(7-10)16(26)23-17(20)21;;/h5-8H,3-4H2,1-2H3,(H,22,25)(H4,20,21,23,26);2*1H
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| InChIKey |
NPUVTFLPUFCAOB-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sodium/hydrogen exchanger (SLC) | Target Info | Modulator | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Cardiac muscle contraction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Regulation of actin cytoskeleton | ||||
| Thyroid hormone signaling pathway | ||||
| Salivary secretion | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Bile secretion | ||||
| Proteoglycans in cancer | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009190) | |||
| REF 2 | Protective effect of FR183998, a Na+/H+ exchanger inhibitor, and its inhibition of iNOS induction in hepatic ischemia-reperfusion injury in rats. Shock. 2008 Sep;30(3):311-7. | |||
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