Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05CBJ
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| Former ID |
DIB008702
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| Drug Name |
PA-799
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| Synonyms |
MEN1611; CH-5033855; CH-5061565; CH-5089788; CH-5108135; CH-5111436; CH-5138134
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| Drug Type |
Small molecular drug
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| Indication | Colorectal cancer [ICD-11: 2B91.Z] | Phase 1/2 | [1] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [2], [3] | ||
| Company |
Chugai Pharmaceutical Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C15H19N7O3S
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| Canonical SMILES |
CS(=O)(=O)N1CCC2=C(N=C(N=C21)N3CCOCC3)C4=CN=C(N=C4)N
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| InChI |
1S/C15H19N7O3S/c1-26(23,24)22-3-2-11-12(10-8-17-14(16)18-9-10)19-15(20-13(11)22)21-4-6-25-7-5-21/h8-9H,2-7H2,1H3,(H2,16,17,18)
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| InChIKey |
JEGHXKRHKHPBJD-UHFFFAOYSA-N
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| CAS Number |
CAS 1007207-67-1
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04495621) MEN1611 With Cetuximab in Metastatic Colorectal Cancer (C-PRECISE-01) (C-PRECISE-01). U.S. National Institutes of Health. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7743). | |||
| REF 3 | The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin Cancer Res. 2011 May 15;17(10):3272-81. | |||
| REF 4 | Company report (Chugai-pharm) | |||
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