Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05BIN
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| Former ID |
DIB008738
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| Drug Name |
F-14512
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| Synonyms |
Polyamine-epipodophyllotoxin conjugate (cancer), Pierre Fabre
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1/2 | [1] | |
| Company |
Pierre Fabre SA
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| Structure |
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Download2D MOL |
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| Formula |
C33H47N5O8
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| Canonical SMILES |
COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)NC(=O)CNCCCNCCCCNCCCN
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| InChI |
1S/C33H47N5O8/c1-42-26-13-20(14-27(43-2)32(26)40)29-21-15-24-25(46-19-45-24)16-22(21)31(23-18-44-33(41)30(23)29)38-28(39)17-37-12-6-11-36-9-4-3-8-35-10-5-7-34/h13-16,23,29-31,35-37,40H,3-12,17-19,34H2,1-2H3,(H,38,39)/t23-,29+,30-,31+/m0/s1
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| InChIKey |
NUZMJDHDPVKFJN-TYDXHICZSA-N
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| CAS Number |
CAS 866874-63-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026777) | |||
| REF 2 | Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.Apoptosis.2012 Apr;17(4):364-76. | |||
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