Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05AAW
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| Former ID |
DIB010068
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| Drug Name |
VR-776
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| Synonyms |
Premature ejaculation therapy (inhaled, PowerHale), Vectura
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| Drug Type |
Small molecular drug
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| Indication | Premature ejaculation [ICD-11: HA03.0Z; ICD-10: F52.4; ICD-9: 302.75] | Discontinued in Phase 1 | [1] | |
| Company |
Vectura Group plc
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| Structure |
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Download2D MOL |
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| Formula |
C19H24Cl2N2
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| Canonical SMILES |
CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl
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| InChI |
1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
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| InChIKey |
WIMWMKZEIBHDTH-UHFFFAOYSA-N
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| CAS Number |
CAS 17321-77-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
855785, 3146444, 7847876, 8150146, 8192195, 10321173, 11528647, 14925416, 17404870, 24278087, 24714730, 25624751, 26514064, 26543492, 26613159, 26680358, 26747483, 43125096, 50064402, 50106071, 50122894, 50122895, 53777413, 56311677, 56422907, 57316916, 79827483, 85084917, 85149187, 85174244, 88565714, 92125084, 92303620, 103770693, 103819575, 103913653, 104170176, 104342415, 117447143, 124637328, 124891638, 124891639, 125312387, 125342946, 126617326, 126645822, 126664318, 135027196, 135610155, 135697887
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| ChEBI ID |
CHEBI:3755
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Prevotella copri
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Clomipramine hydrochloride (adjusted p-values: 6.42E-04). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022099) | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
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