Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04YCE
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| Former ID |
DIB003036
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| Drug Name |
Pidotimod
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| Synonyms |
Pgt-1A; 117241-40-4; 3-Pyroglutamylthiazolidine-4-carboxylic acid; 3-(5-oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid; NSC678119; 3-((5-Oxo-2-pyrrolidinyl)carbonyl)-4-thiazolidinecarboxylic acid; 3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid; 4-Thiazolidinecarboxylic acid, 3-((5-oxo-2-pyrrolidinyl)carbonyl)-; C9H12N2O4S; 3-(5-oxoprolyl)-1,3-thiazolidine-4-carboxylic acid; ACMC-20emtr; ACMC-209vwo; AC1L3FWE; MLS006011471; SCHEMBL9342892; CTK0H7615; MolPort-004-328-744; 4-Thiazolidinecarboxylicacid, 3-[[(2S)-5-
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| Drug Type |
Small molecular drug
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| Indication | Urinary tract infection [ICD-11: GC08; ICD-10: N39, N39.0; ICD-9: 599] | Withdrawn from market | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H12N2O4S
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| Canonical SMILES |
C1CC(=O)NC1C(=O)N2CSCC2C(=O)O
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| InChI |
1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1
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| InChIKey |
UUTKICFRNVKFRG-WDSKDSINSA-N
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| CAS Number |
CAS 121808-62-6
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:94618
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.84; p = 0.026). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.392; p = 0.025). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -1.072; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.974; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -1.01; p = 0.008). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.564; p = 0.015). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.965; p = 0.004). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.757; p = 0.033). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -1.05; p = 0.006). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -0.896; p = 0.007). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.591; p = 0.002). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.828; p = 0.02). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.812; p = 0.008). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.872; p = 0.007). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.375; p = 0.016). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.432; p = 0.006). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.557; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Blautia hansenii DSM20583 (log2FC = -4.3; p = 0.01). | |||
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Studied Microbe: Clostridium sp.
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pidotimod can be metabolized by Clostridium sp. (log2FC = -4.178; p = 0.003). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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