Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04UCV
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| Former ID |
DNC004320
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| Drug Name |
8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole
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| Synonyms |
CHEMBL443258; 8-chloro-1H,2H,3H,4H-pyrazino[1,2-a]indole; 126718-22-7; 8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole; SCHEMBL5917499; MolPort-022-445-855; BDBM50108304; ZINC13586842; AKOS022692454; MCULE-6563903231; NE39901; 8-chloro-1,2,3,4-tetrahydropyrazino[1,2-a]indole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H11ClN2
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| Canonical SMILES |
C1CN2C(=CC3=C2C=CC(=C3)Cl)CN1
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| InChI |
1S/C11H11ClN2/c12-9-1-2-11-8(5-9)6-10-7-13-3-4-14(10)11/h1-2,5-6,13H,3-4,7H2
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| InChIKey |
QKGDOWUCRMVFPY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | |||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8. | |||
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