Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04TZA
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| Drug Name |
PF-04957325
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| Synonyms |
GTPL9659; SCHEMBL17545207; ZINC165851270; AKOS032945026; CS-6185; HY-15426
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| Indication | Inflammation [ICD-11: 1A00-CA43.1] | Investigative | [1] | |
| Itching [ICD-11: 1F28-1G07] | Investigative | [1] | ||
| Structure |
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Download2D MOL |
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| Formula |
C14H15F3N8OS
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| Canonical SMILES |
C1COC(CN1CC2=NC=CS2)CN3C4=NC(=NC(=C4N=N3)N)C(F)(F)F
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| InChI |
1S/C14H15F3N8OS/c15-14(16,17)13-20-11(18)10-12(21-13)25(23-22-10)6-8-5-24(2-3-26-8)7-9-19-1-4-27-9/h1,4,8H,2-3,5-7H2,(H2,18,20,21)/t8-/m1/s1
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| InChIKey |
VNLPYEMGHGDRRZ-MRVPVSSYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 8 (PDE8) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.Front Pharmacol. 2016 Aug 23;7:259. | |||
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