Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04TEF
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| Former ID |
DIB011814
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| Drug Name |
Alpha-1 antitrypsin
|
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| Synonyms |
AAT, Transgene; Alpha-1 antitrypsin, Transgene
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| Indication | Coagulation defect [ICD-11: 3B10.0] | Phase 2 | [1] | |
| Bacillus anthracis infection [ICD-11: 1G40] | Phase 1/2 | [2], [3] | ||
| Company |
Transgene SA
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cationic trypsinogen (PRSS1) | Target Info | Modulator | [4], [5], [6] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Pancreatic secretion | ||||
| Protein digestion and absorption | ||||
| Influenza A | ||||
| Reactome | Activation of Matrix Metalloproteinases | |||
| Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
| WikiPathways | Activation of Matrix Metalloproteinases | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Technology evaluation: transgenic alpha-1-antitrypsin (AAT), PPL therapeutics. Curr Opin Mol Ther. 2000 Apr;2(2):199-204. | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033072) | |||
| REF 3 | Alpha-1 antitrypsin reduces severity of pseudomonas pneumonia in mice and inhibits epithelial barrier disruption and pseudomonas invasion of respiratory epithelial cells. Front Public Health. 2013 Jun 21;1:19. | |||
| REF 4 | US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT. | |||
| REF 5 | EP patent application no. 2490711, A pharmaceutical composition for treating cancer comprising trypsinogen and/or chymotrypsinogen and an active agent selected from a selenium compound, a vanilloid compound and a cytoplasmic glycolysis reduction agent). | |||
| REF 6 | Expression of human alpha 1 antitrypsin in transgenic sheep. Cytotechnology. 1992;9(1-3):77-84. | |||
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