Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04SPK
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| Former ID |
DCL000326
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| Drug Name |
Seratrodast
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| Synonyms |
Bronica; A 73001; AA 2414; ABT 001; Abbott 73001; A-73001; AA-2414; ABT-001; Abbott-73001; Bronica (TN); Seratrodast [USAN:INN]; Seratrodast (JAN/USAN/INN); (+-)-2,4,5-Trimethyl-3,6-dioxo-zeta-phenyl-1,4-cyclohexadiene-1-heptanoic acid; (+-)-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid; 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid; 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid
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| Drug Type |
Small molecular drug
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| Indication | Allergic asthma [ICD-11: CA23.0; ICD-10: J45.0] | Discontinued in Phase 3 | [1] | |
| Company |
Takeda Pharma
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H26O4
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| Canonical SMILES |
CC1=C(C(=O)C(=C(C1=O)C)C(CCCCCC(=O)O)C2=CC=CC=C2)C
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| InChI |
1S/C22H26O4/c1-14-15(2)22(26)20(16(3)21(14)25)18(17-10-6-4-7-11-17)12-8-5-9-13-19(23)24/h4,6-7,10-11,18H,5,8-9,12-13H2,1-3H3,(H,23,24)
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| InChIKey |
ZBVKEHDGYSLCCC-UHFFFAOYSA-N
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| CAS Number |
CAS 112665-43-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5584519, 7848186, 7980464, 8151634, 12013832, 14876439, 29221613, 48414587, 49830166, 49880326, 50125893, 57321321, 74807047, 81094522, 85210460, 91615962, 103267220, 103808130, 104300620, 117584139, 121362280, 126671552, 129880275, 131294765, 134224157, 134338980, 134340368, 135017832, 135371343, 135697578, 137010169, 137619469, 144076118, 144206327, 152051244, 162011717, 162176641, 162311097, 162776232, 164233644, 164814859, 165235264, 166226111, 170465940, 175607568, 179148424, 184546209, 204380861, 210279852, 210282175
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| ChEBI ID |
CHEBI:32126
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| SuperDrug ATC ID |
R03DX06
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thromboxane A2 receptor (TBXA2R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Platelet activation | ||||
| Reactome | Prostanoid ligand receptors | |||
| G alpha (q) signalling events | ||||
| G alpha (12/13) signalling events | ||||
| Thromboxane signalling through TP receptor | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Small Ligand GPCRs | ||||
| Signal amplification | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Thromboxane A2 inhibition: therapeutic potential in bronchial asthma. Am J Respir Med. 2002;1(1):11-7. | |||
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