Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04RZZ
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| Former ID |
DIB008503
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| Drug Name |
A-5021
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| Synonyms |
(-)-9-[1(S),2(R)-Bis(hydroxymethyl)cyclopropan-1-ylmethyl]guanine; 145512-85-2
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Discontinued in Phase 2 | [1] | |
| Structure |
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Download2D MOL |
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| Canonical SMILES |
C1C(C1(CN2C=NC3=C2NC(=NC3=O)N)CO)CO
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpesvirus DNA polymerase (KSHV DNAP) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009510) | |||
| REF 2 | Mode of action of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl) cycloprop-1'-yl]methyl]guanine (A-5021) against herpes simplex virus type 1 and type 2 and varicella-zoster virus. Antimicrob Agents Chemother. 1998 Aug;42(8):2095-102. | |||
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