Drug Information
Drug General Information | Top | |||
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Drug ID |
D04OTF
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Former ID |
DNC012133
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Drug Name |
N-(4-Chloro-3-methanesulfonyl-benzoyl)-guanidine
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Synonyms |
CHEMBL62469
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C9H10ClN3O3S
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Canonical SMILES |
CS(=O)(=O)C1=C(C=CC(=C1)C(=O)N=C(N)N)Cl
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InChI |
1S/C9H10ClN3O3S/c1-17(15,16)7-4-5(2-3-6(7)10)8(14)13-9(11)12/h2-4H,1H3,(H4,11,12,13,14)
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InChIKey |
AXVSLAVXNQSEKO-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Sodium/hydrogen exchanger 1 (SLC9A1) | Target Info | Inhibitor | [1] |
Sodium/hydrogen exchanger 3 (SLC9A3) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Proximal tubule bicarbonate reclamation | |||
Protein digestion and absorption | ||||
Bile secretion | ||||
Mineral absorption | ||||
cAMP signaling pathway | ||||
Cardiac muscle contraction | ||||
Adrenergic signaling in cardiomyocytes | ||||
Regulation of actin cytoskeleton | ||||
Thyroid hormone signaling pathway | ||||
Salivary secretion | ||||
Gastric acid secretion | ||||
Pancreatic secretion | ||||
Proteoglycans in cancer | ||||
Pathway Interaction Database | Endothelins | |||
RhoA signaling pathway | ||||
ErbB1 downstream signaling | ||||
Signaling mediated by p38-alpha and p38-beta | ||||
Reactome | Hyaluronan uptake and degradation | |||
WikiPathways | SIDS Susceptibility Pathways | |||
Regulation of Actin Cytoskeleton | ||||
G Protein Signaling Pathways | ||||
Glycosaminoglycan metabolism | ||||
Osteoclast Signaling |
References | Top | |||
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REF 1 | (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. |
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