Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04ODO
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| Former ID |
DIB005801
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| Drug Name |
GSK-256073
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| Synonyms |
GPCR agonists (hyperlipidemia), GSK; GSK-256073-A; HM74A receptor agonists (hyperlipidemia), GSK; G protein-coupled receptor agonists (hyperlipidemia), GSK
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| Drug Type |
Small molecular drug
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| Indication | Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Phase 2 | [1], [2] | |
| Company |
GlaxoSmithKline plc
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| Structure |
 |
Download2D MOL
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| Formula |
C10H13ClN4O2
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| Canonical SMILES |
CCCCCN1C2=C(C(=O)NC1=O)NC(=N2)Cl
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| InChI |
1S/C10H13ClN4O2/c1-2-3-4-5-15-7-6(12-9(11)13-7)8(16)14-10(15)17/h2-5H2,1H3,(H,12,13)(H,14,16,17)
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| InChIKey |
CGAMDQCXAAOFSR-UHFFFAOYSA-N
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| CAS Number |
CAS 862892-90-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nicotinic acid receptor (HCAR2) | Target Info | Agonist | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8470). | |||
| REF 2 | GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus. Diabetes Obes Metab. 2013 Nov;15(11):1013-21. | |||
| REF 3 | Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8. | |||
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