Drug Information
Drug General Information | Top | |||
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Drug ID |
D04NVK
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Former ID |
DIB015080
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Drug Name |
ShRNA molecule silencing DNAPK radiosensitizer
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Synonyms |
ShRNA molecule silencing DNAPK radiosensitizer (PSMA-targeting RNA aptamer-based delivery, prostate cancer)
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Drug Type |
Aptamer
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Indication | Prostate cancer [ICD-11: 2C82.0; ICD-10: C61; ICD-9: 185] | Investigative | [1] | |
Company |
Johns Hopkins University School of Medicine
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Target and Pathway | Top | |||
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Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | . | [1] |
KEGG Pathway | Non-homologous end-joining | |||
Cell cycle | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
Coregulation of Androgen receptor activity | ||||
Class I PI3K signaling events mediated by Akt | ||||
BARD1 signaling events | ||||
Reactome | Nonhomologous End-Joining (NHEJ) | |||
WikiPathways | DNA Damage Response | |||
Non-homologous end joining | ||||
FAS pathway and Stress induction of HSP regulation | ||||
Cytosolic sensors of pathogen-associated DNA | ||||
Retinoblastoma (RB) in Cancer | ||||
Prostate Cancer | ||||
Double-Strand Break Repair | ||||
Cell Cycle | ||||
miRNA Regulation of DNA Damage Response |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2800). |
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