Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04NAQ
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| Former ID |
DNCL002853
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| Drug Name |
Emricasan
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| Synonyms |
Emricasan; 254750-02-2; IDN-6556; PF-03491390; UNII-P0GMS9N47Q; (S)-3-((S)-2-(2-(2-TERT-BUTYLPHENYLAMINO)-2-OXOACETAMIDO)PROPANAMIDO)-4-OXO-5-(2,3,5,6-TETRAFLUOROPHENOXY)PENTANOIC ACID; P0GMS9N47Q; (S)-3-((S)-2-(2-((2-(tert-Butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid; PF 03491390; Emricasan [USAN:INN]; Emricasan (USAN/INN); SCHEMBL3288801; GTPL6508; CHEMBL197672; DTXSID10180160; MolPort-027-835-564; C26H27F4N3O7; BCP07463; IDN 6556; EX-A1659; s7775; 2073AB; ZINC14191207
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| Drug Type |
Small molecular drug
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| Indication | Hepatic fibrosis [ICD-11: DB93.0; ICD-10: K74.0; ICD-9: 709.2] | Phase 2 | [1], [2] | |
| Liver cirrhosis [ICD-11: DB93.1] | Phase 2 | [3] | ||
| Company |
Conatus Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C26H27F4N3O7
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| Canonical SMILES |
CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C
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| InChI |
1S/C26H27F4N3O7/c1-12(31-24(38)25(39)32-16-8-6-5-7-13(16)26(2,3)4)23(37)33-17(10-19(35)36)18(34)11-40-22-20(29)14(27)9-15(28)21(22)30/h5-9,12,17H,10-11H2,1-4H3,(H,31,38)(H,32,39)(H,33,37)(H,35,36)/t12-,17-/m0/s1
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| InChIKey |
SCVHJVCATBPIHN-SJCJKPOMSA-N
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| CAS Number |
CAS 254750-02-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6508). | |||
| REF 2 | The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. Liver Int. 2015 Mar;35(3):953-66. | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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