Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04MSI
|
|||
| Former ID |
DIB021052
|
|||
| Drug Name |
threo-3-methylglutamate
|
|||
| Synonyms |
(+/-)-threo-3-methylglutamic acid
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C6H11NO4
|
|||
| Canonical SMILES |
CC(CC(=O)O)C(C(=O)O)N
|
|||
| InChI |
1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)
|
|||
| InChIKey |
FHJNAFIJPFGZRI-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 2445-97-8
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Excitatory amino acid transporter 2 (SLC1A2) | Target Info | Inhibitor | [2] |
| Excitatory amino acid transporter 4 (SLC1A6) | Target Info | Inhibitor | [3] | |
| Panther Pathway | Ionotropic glutamate receptor pathway | |||
| Metabotropic glutamate receptor group III pathway | ||||
| WikiPathways | Amyotrophic lateral sclerosis (ALS) | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4573). | |||
| REF 2 | Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol Pharmacol. 1997 May;51(5):809-15. | |||
| REF 3 | Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J Neurochem. 2001 Apr;77(2):550-7. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.