Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04MRQ
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| Former ID |
DIB014691
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| Drug Name |
Irsogladine
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| Synonyms |
Gaslon N; Irsogladine malate; Irsogladine maleate; MN-1695
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| Drug Type |
Small molecular drug
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| Indication | Metastatic malignant neoplasm [ICD-11: 2D50-2E09] | Approved | [1] | |
| Company |
Nippon Shinyaku Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C9H7Cl2N5
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| Canonical SMILES |
C1=CC(=C(C=C1Cl)C2=NC(=NC(=N2)N)N)Cl
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| InChI |
1S/C9H7Cl2N5/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7/h1-3H,(H4,12,13,14,15,16)
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| InChIKey |
ATCGGEJZONJOCL-UHFFFAOYSA-N
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| CAS Number |
CAS 57381-26-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:93307
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium ruminantium
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Irsogladine maleate can be metabolized by Bifidobacterium ruminantium (log2FC = -0.45; p = 0.016). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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