Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04LCQ
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| Former ID |
DNAP001264
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| Drug Name |
Tafluprost
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| Synonyms |
Zioptan (TN)
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| Drug Type |
Small molecular drug
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| Indication | Glaucoma/ocular hypertension [ICD-11: 9C61; ICD-9: 365] | Approved | [1], [2], [3], [4] | |
| Company |
Merck
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H34F2O5
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| Canonical SMILES |
CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC=C2)(F)F)O)O
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| InChI |
1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1
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| InChIKey |
WSNODXPBBALQOF-VEJSHDCNSA-N
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| CAS Number |
CAS 209860-87-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14833400, 16479496, 22395198, 24159835, 45290755, 47207932, 51701855, 58832503, 126666556, 135262832, 136926196, 137248721, 139498527, 142864543, 160645612, 162200065, 174549070, 175268334, 175427102, 187051754, 198993062, 210279761, 210282084, 223663993, 227511615, 251916091, 251917439, 252216358, 252457570, 252815367
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| ChEBI ID |
CHEBI:66899
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| ADReCS Drug ID | BADD_D02108 | |||
| SuperDrug ATC ID |
S01EE05
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin F2-alpha receptor (PTGFR) | Target Info | Modulator | [4] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | Prostanoid ligand receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7451). | |||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
| REF 3 | Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation. Mol Endocrinol. 2010 Feb;24(2):436-46. | |||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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