Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04GJN
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| Former ID |
DAP000861
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| Drug Name |
Megestrol
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| Synonyms |
Chronopil; Megestrolo; Megestrolo [DCIT]; Chronopil (TN); Megace (TN); Megestrol (INN); Megestrol [INN:BAN]; Megestrolum [INN-Latin]; (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one; 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65] | Approved | [1] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
Bristol Myers Squibb
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| Structure |
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Download2D MOL |
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| Formula |
C22H30O3
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| Canonical SMILES |
CC1=CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4(C1=CC(=O)CC4)C
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| InChI |
1S/C22H30O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h11-12,16-18,25H,5-10H2,1-4H3/t16-,17+,18+,20-,21+,22+/m1/s1
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| InChIKey |
VXIMPSPISRVBPZ-NWUMPJBXSA-N
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| CAS Number |
CAS 3562-63-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ADReCS Drug ID | BADD_D01371 | |||
| SuperDrug ATC ID |
G03AC05; G03DB02; L02AB01
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| SuperDrug CAS ID |
cas=003562638
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides dorei DSM 17855
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.712; p = 0.018). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.507; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.689; p = 0.023). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.537; p = 0.035). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.707; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.461; p = 0.05). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.553; p = 0.023). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.616; p = 0.048). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.386; p = 0.002). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.469; p = 0.009). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.679; p = 0.0). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.756; p = 0.032). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.49; p = 0.02). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Odoribacter splanchnicus (log2FC = -0.566; p = 0.009). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.43; p = 0.003). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -0.401; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium ruminantium
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Bifidobacterium ruminantium (log2FC = -0.375; p = 0.015). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Escherichia coli BW25113
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Escherichia coli BW25113 (log2FC = -0.332; p = 0.025). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.622; p = 0.005). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -3.024; p = 0.001). | |||
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Studied Microbe: Clostridium sp.
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol acetate can be metabolized by Clostridium sp. (log2FC = -0.59; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [3] | |||
| Experimental Method | High-throughput screening | |||
| Description | Megestrol Acetate can be metabolized by gut microbiota. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Progesterone receptor (PGR) | Target Info | Binder | [4] |
| KEGG Pathway | Oocyte meiosis | |||
| Progesterone-mediated oocyte maturation | ||||
| Pathway Interaction Database | Cellular roles of Anthrax toxin | |||
| Reactome | Nuclear signaling by ERBB4 | |||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Ovarian Infertility Genes | |||
| Signaling by ERBB4 | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Hormonal therapy in epithelial ovarian cancer. Expert Rev Anticancer Ther. 2006 Jan;6(1):43-7. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 4 | Focus on anastrozole and breast cancer. Curr Med Res Opin. 2003;19(8):683-8. | |||
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