Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04FPW
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| Former ID |
DNC004751
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| Drug Name |
Des-AA1,4,5,13-[Tyr2,D-Trp8]-SRIF
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| Synonyms |
CHEMBL438630; Des-AA1,4,5,13-[Tyr2,D-Trp8]-SRIF
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C74H88N12O14S2
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| Canonical SMILES |
CC(C)NCC1=CC=C(C=C1)CC2C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC3=CNC4=CC=CC=C43)CC5=CC=CC=C5)CC6=CC=CC=C6)NC(=O)C(CC7=CC=C(C=C7)O)N)C(=O)O)C(C)O)CC8=CC=CC=C8)C(C)O
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| InChI |
1S/C74H88N12O14S2/c1-42(2)76-38-50-26-24-49(25-27-50)36-58-69(94)85-63(43(3)87)72(97)82-59(35-47-20-12-7-13-21-47)70(95)86-64(44(4)88)73(98)84-62(74(99)100)41-102-101-40-61(83-65(90)54(75)32-48-28-30-52(89)31-29-48)71(96)80-57(34-46-18-10-6-11-19-46)66(91)78-56(33-45-16-8-5-9-17-45)67(92)81-60(68(93)79-58)37-51-39-77-55-23-15-14-22-53(51)55/h5-31,39,42-44,54,56-64,76-77,87-89H,32-38,40-41,75H2,1-4H3,(H,78,91)(H,79,93)(H,80,96)(H,81,92)(H,82,97)(H,83,90)(H,84,98)(H,85,94)(H,86,95)(H,99,100)/t43-,44-,54+,56+,57-,58+,59+,60+,61-,62+,63-,64-/m1/s1
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| InChIKey |
GYAXOXYXFASSKI-GAZSGENXSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Somatostatin receptor type 1 (SSTR1) | Target Info | Inhibitor | [1] |
| Somatostatin receptor type 3 (SSTR3) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| cAMP signaling pathway | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. | |||
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