Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04FBR
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| Former ID |
DAP000783
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| Drug Name |
Mycophenolate mofetil
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| Synonyms |
mycophenolate mofetil; 128794-94-5; CellCept; 115007-34-6; RS 61443; RS-61443; Munoloc; Mycophenolic acid morpholinoethyl ester; TM-MMF; Mycophenylate mofetil; Mycophenolatemofetil; UNII-9242ECW6R0; HSDB 7436; Cellcept (TN); 2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate; CHEBI:8764; C23H31NO7; Mycophenolate mofetil (CellCept); 9242ECW6R0; 2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate; Myfenax; RS-61443-190; CellCept; MMF; CellCept (TN); ME-MPA; MMF CellCept(TM); R-99; Mycophenolate mofetil (JAN/USAN); CellCept, RS 61443, TM-MMF, Mycophenolate mofetil; 2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate; 2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate; 2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate;4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
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| Drug Type |
Small molecular drug
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| Indication | Organ transplant rejection [ICD-11: NE84; ICD-9: 279.5, 996] | Approved | [1], [2] | |
| Pemphigus vulgaris [ICD-11: EB40; ICD-10: L10.0, L10.1; ICD-9: 694.4] | Phase 3 | [1], [2] | ||
| Immune System disease [ICD-11: 4A01-4B41; ICD-10: D80-D89] | Investigative | [3] | ||
| Therapeutic Class |
Immunosuppressive Agents
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| Company |
Roche
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H31NO7
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| Canonical SMILES |
CC1=C2COC(=O)C2=C(C(=C1OC)CC=C(C)CCC(=O)OCCN3CCOCC3)O
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| InChI |
1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+
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| InChIKey |
RTGDFNSFWBGLEC-SYZQJQIISA-N
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| CAS Number |
CAS 128794-94-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10110, 537396, 623972, 7847817, 8616507, 12014254, 14758955, 29215410, 39289999, 46505626, 48416299, 49830660, 49976609, 50064190, 56310881, 56312885, 57358003, 62129612, 77319688, 80954261, 92308999, 92718908, 93619754, 96099842, 103524891, 103831140, 104253178, 113854519, 117622077, 118053002, 124757298, 125164102, 125275456, 126592936, 126621236, 126622394, 126651543, 126669998, 126682700, 131295332, 131297141, 132003527, 134338068, 134339833, 135016986, 135039794, 136949095, 137004579, 142385187, 144075766
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| ChEBI ID |
CHEBI:8764
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| ADReCS Drug ID | BADD_D01507 ; BADD_D01508 | |||
| SuperDrug ATC ID |
L04AA06
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -1.065; p = 0.021). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.643; p = 0.005). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.917; p = 0.0). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -0.525; p = 0.017). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.662; p = 0.004). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.758; p = 0.004). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.654; p = 0.013). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.48; p = 0.016). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.707; p = 0.009). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.79; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.578; p = 0.002). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -0.413; p = 0.023). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -0.462; p = 0.004). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.507; p = 0.003). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.665; p = 0.001). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.712; p = 0.008). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.693; p = 0.006). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -5.877; p = 0.0). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.806; p = 0.025). | |||
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Studied Microbe: Bacteroides WH2
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides WH2 (log2FC = -1.079; p = 0.007). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.579; p = 0.013). | |||
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Studied Microbe: Odoribacter splanchnicus
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Odoribacter splanchnicus (log2FC = -0.917; p = 0.001). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -1.462; p = 0.0). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.657; p = 0.002). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -0.731; p = 0.0). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Pretovella copri DSM 18205 (log2FC = -8.799; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis ATCC 15703
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -0.438; p = 0.012). | |||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -6.3; p = 0.014). | |||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -0.503; p = 0.009). | |||
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Studied Microbe: Bifidobacterium ruminantium
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bifidobacterium ruminantium (log2FC = -0.781; p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella intestinalis DSM 13280
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -0.454; p = 0.034). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -0.831; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Edwardsiella tarda ATCC 23685
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Edwardsiella tarda ATCC 23685 (log2FC = -0.364; p = 0.021). | |||
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Studied Microbe: Enterobacter cancerogenus ATCC35316
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -0.528; p = 0.014). | |||
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Studied Microbe: Escherichia coli BW25113
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Escherichia coli BW25113 (log2FC = -0.593; p = 0.002). | |||
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Studied Microbe: Proteus penneri ATCC 35198
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Proteus penneri ATCC 35198 (log2FC = -0.366; p = 0.006). | |||
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Studied Microbe: Providencia alcalifaciens DSM 30120
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Providencia alcalifaciens DSM 30120 (log2FC = -0.493; p = 0.018). | |||
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Studied Microbe: Providencia rettgeri DSM 1131
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Providencia rettgeri DSM 1131 (log2FC = -0.49; p = 0.003). | |||
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Studied Microbe: Providencia stuartii ATCC 25827
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Providencia stuartii ATCC 25827 (log2FC = -0.408; p = 0.002). | |||
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Studied Microbe: Salmonella typhimurium LT2
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Salmonella typhimurium LT2 (log2FC = -0.584; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium ramosum DSM 1402
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -1.098; p = 0.0). | |||
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Studied Microbe: Clostridium spiroforme DSM1552
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -0.623; p = 0.005). | |||
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Studied Microbe: Eubacterium biforme DSM 3989
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -0.818; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerostipes sp.
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Anaerostipes sp. (log2FC = -0.553; p = 0.043). | |||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -0.353; p = 0.035). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.89; p = 0.001). | |||
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Studied Microbe: Blautia luti DSM 14534
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Blautia luti DSM 14534 (log2FC = -1.223; p = 0.0). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -0.609; p = 0.011). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -1.044; p = 0.027). | |||
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Studied Microbe: Clostridium difficile 120
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Clostridium difficile 120 (log2FC = -1.175; p = 0.003). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -0.455; p = 0.011). | |||
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Studied Microbe: Clostridium scindens ATCC 35704
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Clostridium scindens ATCC 35704 (log2FC = -0.736; p = 0.003). | |||
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Studied Microbe: Clostridium sp.
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Clostridium sp. (log2FC = -0.897; p = 0.002). | |||
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Studied Microbe: Coprococcus comes ATCC 27758
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -0.446; p = 0.018). | |||
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Studied Microbe: Dorea formicigenerans ATCC 27755
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -0.382; p = 0.035). | |||
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Studied Microbe: Enterocloster bolteae ATCC BAA-613
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -0.436; p = 0.012). | |||
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Studied Microbe: Eubacterium hallii DSM3353
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Eubacterium hallii DSM3353 (log2FC = -0.374; p = 0.004). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -0.617; p = 0.012). | |||
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Studied Microbe: Roseburia intestinalis L1-82
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Roseburia intestinalis L1-82 (log2FC = -0.579; p = 0.002). | |||
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Studied Microbe: Ruminococcus torques ATCC 27756
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -0.456; p = 0.012). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -0.675; p = 0.0). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus faecalis V583
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Enterococcus faecalis V583 (log2FC = -6.289; p = 0.003). | |||
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Studied Microbe: Lactobacillus reuteri CF48-3A
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -0.534; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -0.668; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -0.517; p = 0.006). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate mofetil can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -0.742; p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [5] | |||
| Metabolic Reaction | Ester hydrolysis | |||
| Experimental Method | High-throughput screening | |||
| Description | Mycophenolate Mofetil can be metabolized by gut microbiota through ester hydrolysis. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) | Target Info | Inhibitor | [6] |
| Prostaglandin E2 receptor EP2 (PTGER2) | Target Info | Modulator | [3] | |
| BioCyc | Purine nucleotides degradation | |||
| Urate biosynthesis/inosine 5'-phosphate degradation | ||||
| Guanosine nucleotides de novo biosynthesis | ||||
| Superpathway of purine nucleotide salvage | ||||
| Purine nucleotides de novo biosynthesis | ||||
| Guanosine ribonucleotides de novo biosynthesis | ||||
| KEGG Pathway | Purine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Renin secretion | ||||
| Pathways in cancer | ||||
| Panther Pathway | De novo purine biosynthesis | |||
| Reactome | Purine ribonucleoside monophosphate biosynthesis | |||
| Prostanoid ligand receptors | ||||
| G alpha (s) signalling events | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Ovarian Infertility Genes | ||||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6831). | |||
| REF 2 | Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 341). | |||
| REF 4 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 5 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 6 | Clinical pipeline report, company report or official report of Roche (2009). | |||
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