Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04DKL
|
|||
| Former ID |
DNCL002568
|
|||
| Drug Name |
ALT-836
|
|||
| Indication | Adult respiratory distress syndrome [ICD-11: CB00; ICD-10: J80; ICD-9: 518.5, 518.82] | Phase 2 | [1] | |
| Company |
Altor BioScience
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tissue factor (F3) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Complement and coagulation cascades | |||
| NetPath Pathway | IL4 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| TWEAK Signaling Pathway | ||||
| Panther Pathway | Angiogenesis | |||
| Blood coagulation | ||||
| Pathwhiz Pathway | Coagulation | |||
| Reactome | Extrinsic Pathway of Fibrin Clot Formation | |||
| WikiPathways | Complement and Coagulation Cascades | |||
| Formation of Fibrin Clot (Clotting Cascade) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00879606) Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome. U.S. National Institutes of Health. | |||
| REF 2 | ImmunoPET of tissue factor expression in triple-negative breast cancer with a radiolabeled antibody Fab fragment. Eur J Nucl Med Mol Imaging. 2015 Jul;42(8):1295-303. | |||
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