Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04CVC
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| Former ID |
DNC004888
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| Drug Name |
4-Amino-3-fluoro-benzenesulfonamide
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| Synonyms |
4-amino-3-fluorobenzenesulfonamide
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C6H7FN2O2S
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| Canonical SMILES |
C1=CC(=C(C=C1S(=O)(=O)N)F)N
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| InChI |
1S/C6H7FN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11)
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| InChIKey |
HVFBADWBKHAPKV-UHFFFAOYSA-N
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| CAS Number |
CAS 2368-84-5
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. | |||
| REF 2 | Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. | |||
| REF 3 | Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. | |||
| REF 4 | Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. | |||
| REF 5 | Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. | |||
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