Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04CJE
|
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| Former ID |
DIB007768
|
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| Drug Name |
ATF-936
|
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| Indication | Osteoporosis [ICD-11: FB83.0; ICD-10: M85.8] | Phase 1 | [1] | |
| Company |
Novartis AG
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C30H30N2O4
|
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| Canonical SMILES |
CCOC1=C(C=CC(=C1)CN2C3=C(C=C(C=C3)OCC#C)C(=NC2=O)C4=CC=C(C=C4)C(C)C)OC
|
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| InChI |
1S/C30H30N2O4/c1-6-16-36-24-13-14-26-25(18-24)29(23-11-9-22(10-12-23)20(3)4)31-30(33)32(26)19-21-8-15-27(34-5)28(17-21)35-7-2/h1,8-15,17-18,20H,7,16,19H2,2-5H3
|
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| InChIKey |
IIBRYYCFSIBSFT-UHFFFAOYSA-N
|
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| CAS Number |
CAS 717103-89-4
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Extracellular calcium-sensing receptor (CASR) | Target Info | Antagonist | [1] |
| Pathway Interaction Database | E-cadherin signaling in keratinocytes | |||
| Reactome | G alpha (q) signalling events | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans. Bone. 2011 Aug;49(2):233-41. | |||
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