Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03YEM
|
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| Drug Name |
CD19/CD22 CAR T-Cells
|
|||
| Drug Type |
CAR T Cell Therapy (Dual specific)
|
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| Indication | Acute lymphocytic leukaemia [ICD-11: 2B33.3; ICD-10: C91, C91.9] | Phase 1 | [1] | |
| B-cell lymphoma [ICD-11: 2A86; ICD-10: C85.1; ICD-9: 202.8] | Phase 1 | [1] | ||
| B-cell prolymphocytic leukaemia [ICD-11: 2A82.1; ICD-10: C91.3] | Phase 1 | [1] | ||
| leukaemia [ICD-11: 2A60-2B33; ICD-9: 208.9] | Phase 1 | [1] | ||
| Non-hodgkin lymphoma [ICD-11: 2B33.5; ICD-10: C85.9] | Phase 1 | [1] | ||
| Company |
National Cancer Institute (NCI)
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | B-cell receptor CD22 (CD22) | Target Info | CAR-T-Cell-Therapy(Dual specific) | [1] |
| B-lymphocyte surface antigen B4 (CD19) | Target Info | CAR-T-Cell-Therapy(Dual specific) | [1] | |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| Hematopoietic cell lineage | ||||
| B cell receptor signaling pathway | ||||
| PI3K-Akt signaling pathway | ||||
| Epstein-Barr virus infection | ||||
| Primary immunodeficiency | ||||
| NetPath Pathway | IL-7 Signaling Pathway | |||
| Panther Pathway | B cell activation | |||
| Pathway Interaction Database | BCR signaling pathway | |||
| Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | |||
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
| PIP3 activates AKT signaling | ||||
| Constitutive Signaling by Aberrant PI3K in Cancer | ||||
| WikiPathways | B Cell Receptor Signaling Pathway | |||
| Human Complement System | ||||
| Signaling by the B Cell Receptor (BCR) | ||||
| PIP3 activates AKT signaling | ||||
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03448393) CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies | |||
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