Drug Information
Drug General Information | Top | |||
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Drug ID |
D03XDX
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Former ID |
DCL000244
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Drug Name |
Tarazepide
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Synonyms |
Tarazepide (INN)
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Drug Type |
Small molecular drug
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Indication | Gastrointestinal disease [ICD-11: DE2Z] | Discontinued in Phase 2 | [1] | |
Company |
Solvay Pharma
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Structure |
Download2D MOL |
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Formula |
C28H24N4O2
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Canonical SMILES |
CN1C2=CC=CC=C2C(=NC(C1=O)NC(=O)C3=CC4=C5N3CCCC5=CC=C4)C6=CC=CC=C6
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InChI |
1S/C28H24N4O2/c1-31-22-15-6-5-14-21(22)24(18-9-3-2-4-10-18)29-26(28(31)34)30-27(33)23-17-20-12-7-11-19-13-8-16-32(23)25(19)20/h2-7,9-12,14-15,17,26H,8,13,16H2,1H3,(H,30,33)/t26-/m1/s1
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InChIKey |
CZPILLBHPRAPCB-AREMUKBSSA-N
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CAS Number |
CAS 141374-81-4
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Cholecystokinin receptor type A (CCKAR) | Target Info | Antagonist | [2], [3], [4] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Insulin secretion | ||||
Pancreatic secretion | ||||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence. BMC Neurosci. 2012 Jun 8;13:63. | |||
REF 2 | Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. J Physiol Pharmacol. 2007 Dec;58 Suppl 6:65-80. | |||
REF 3 | The ghrelin pentapeptide inhibits the secretion of pancreatic juice in rats. J Physiol Pharmacol. 2006 Dec;57(4):691-700. | |||
REF 4 | Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. Regul Pept. 1998 Nov 30;78(1-3):113-23. |
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