Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03XBB
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| Former ID |
DIB012839
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| Drug Name |
DX-2400
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| Synonyms |
DX-2410; MMP inhibitors (fully human antibodies), Dyax
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Investigative | [1] | |
| Company |
Dyax Corp
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Matrix metalloproteinase-14 (MMP-14) | Target Info | Inhibitor | [1] |
| KEGG Pathway | TNF signaling pathway | |||
| GnRH signaling pathway | ||||
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Signaling events mediated by focal adhesion kinase | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | Senescence and Autophagy in Cancer | |||
| Activation of Matrix Metalloproteinases | ||||
| Degradation of collagen | ||||
| AGE/RAGE pathway | ||||
| Matrix Metalloproteinases | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1638). | |||
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