Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03VXP
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| Drug Name |
PMID25666693-Compound-145
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| Drug Type |
Small molecular drug
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| Indication | Cancer related pain [ICD-11: MG30; ICD-10: R52.1, R52.2] | Patented | [1] | |
| Inflammatory pain [ICD-11: MG30.42; ICD-10: R52, G89] | Patented | [1] | ||
| Neuropathic pain [ICD-11: 8E43.0] | Patented | [1] | ||
| Osteoarthritis pain [ICD-11: MG30.31] | Patented | [1] | ||
| Company |
DAEWOONG PHARMACEUTICAL CO., LTD. KIM, Ji Duck YOON, Hong Chul KIM, In Woo CHO, Min Jae LEE, In Young LEE, Sang Ho PARK, Eun Kyung LIM, Kwon Jo NAM, Sang Hyun
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H18ClF3N4O3
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| Canonical SMILES |
COC1=CN=C(C=C1)N2C(COC3=C(C=CC=C32)C4=NC5=C(N4)C=C(C=C5Cl)C(F)(F)F)CO
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| InChI |
1S/C23H18ClF3N4O3/c1-33-14-5-6-19(28-9-14)31-13(10-32)11-34-21-15(3-2-4-18(21)31)22-29-17-8-12(23(25,26)27)7-16(24)20(17)30-22/h2-9,13,32H,10-11H2,1H3,(H,29,30)/t13-/m0/s1
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| InChIKey |
CKJDUPIYRSXWAL-ZDUSSCGKSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Antagonist | [1] |
| Target's Patent Info | Transient receptor potential cation channel V1 (TRPV1) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. | |||
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