Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03RTK
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| Former ID |
DNAP001309
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| Drug Name |
Trabectedin
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| Synonyms |
Ecteinascidin; Ecteinascidin-743; Et-743; Yondelis (TN)
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Approved | [1], [2] | |
| Ovarian cancer [ICD-11: 2C73; ICD-10: C56; ICD-9: 183] | Phase 3 | [3] | ||
| Company |
PharmaMar
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| Structure |
 |
Download2D MOL |
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| Formula |
C39H43N3O11S
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| Canonical SMILES |
CC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)O)COC(=O)C8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O
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| InChI |
1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1
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| InChIKey |
PKVRCIRHQMSYJX-AIFWHQITSA-N
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| CAS Number |
CAS 114899-77-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10234617, 12014180, 14938004, 16067487, 44437036, 50047052, 50757578, 53788207, 57338466, 99443229, 104380621, 123092462, 126666934, 127334906, 127334907, 135256695, 135652680, 142813748, 144206315, 144206787, 160967837, 164765699, 184812413, 198978374, 223655497, 223736343, 237230406, 243425761, 252552191
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| ChEBI ID |
CHEBI:84050
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| ADReCS Drug ID | BADD_D02253 | |||
| SuperDrug ATC ID |
L01CX01
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2774). | |||
| REF 2 | Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep. 2008 Jun;25(3):475-516. | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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