Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D03RGO
|
|||
Former ID |
DIB005110
|
|||
Drug Name |
CP-331
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Pain [ICD-11: MG30-MG3Z] | Terminated | [1] | |
Company |
Zeria Pharmaceutical Co Ltd
|
|||
Structure |
Download2D MOL |
|||
Formula |
C38H44ClN3O6S
|
|||
Canonical SMILES |
CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OCCSCC(=O)NCCCOC4=CC=CC(=C4)CN5CCCCC5
|
|||
InChI |
1S/C38H44ClN3O6S/c1-27-33(34-23-31(46-2)14-15-35(34)42(27)38(45)29-10-12-30(39)13-11-29)24-37(44)48-20-21-49-26-36(43)40-16-7-19-47-32-9-6-8-28(22-32)25-41-17-4-3-5-18-41/h6,8-15,22-23H,3-5,7,16-21,24-26H2,1-2H3,(H,40,43)
|
|||
InChIKey |
SWFXMFDHMPMWMA-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 127966-70-5
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Histamine H2 receptor (H2R) | Target Info | Modulator | [2] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Gastric acid secretion | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Histamine H2 receptor mediated signaling pathway | ||||
Pathwhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | |||
Gastric Acid Production | ||||
Reactome | Histamine receptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
Secretion of Hydrochloric Acid in Parietal Cells | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001767) | |||
REF 2 | Conjugation of chlorin p(6) to histamine enhances its cellular uptake and phototoxicity in oral cancer cells. Cancer Chemother Pharmacol. 2011 Aug;68(2):359-69. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.