Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03OIA
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| Drug Name |
Macrocycle derivative 14
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| Synonyms |
PMID26161698-Compound-7
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| Drug Type |
Small molecular drug
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| Company |
CT NAC INVESTIGACIONES ONCOLOGICAS CNIO [ES]
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H19N5O
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| Canonical SMILES |
C1CNCCOC2=CC=CC(=C2)C3=CN=C4N3N=C(C=C4)NC1
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| InChI |
1S/C17H19N5O/c1-3-13-11-14(4-1)23-10-9-18-7-2-8-19-16-5-6-17-20-12-15(13)22(17)21-16/h1,3-6,11-12,18H,2,7-10H2,(H,19,21)
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| InChIKey |
LGJSILJEEDDVAZ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cyclin-dependent kinase 8 (CDK8) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Cyclin-dependent kinase 8 (CDK8) | Target's Patent Info | [1] | |
| Reactome | PPARA activates gene expression | |||
| NOTCH1 Intracellular Domain Regulates Transcription | ||||
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | ||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
| Transcriptional regulation of white adipocyte differentiation | ||||
| WikiPathways | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Transcriptional Regulation of White Adipocyte Differentiation | ||||
| Signaling by NOTCH1 | ||||
| SREBP signalling | ||||
| Generic Transcription Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. | |||
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