Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03MAD
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| Former ID |
DCL000507
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| Drug Name |
CP-800569
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| Synonyms |
(2R)-3-[3-(4-chloro-3-ethylphenoxy)-N-[[3-(1,1,2,2-tetrafluoroethoxy)phenyl]methyl]anilino]-1,1,1-trifluoropropan-2-ol
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| Drug Type |
Small molecular drug
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| Indication | Arteriosclerosis [ICD-11: BD40; ICD-10: I70] | Discontinued in Phase 1 | [1] | |
| Company |
Pfizer
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| Structure |
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Download2D MOL |
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| Formula |
C26H23ClF7NO3
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| Canonical SMILES |
CCC1=C(C=CC(=C1)OC2=CC=CC(=C2)N(CC3=CC(=CC=C3)OC(C(F)F)(F)F)CC(C(F)(F)F)O)Cl
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| InChI |
1S/C26H23ClF7NO3/c1-2-17-12-20(9-10-22(17)27)37-19-7-4-6-18(13-19)35(15-23(36)25(30,31)32)14-16-5-3-8-21(11-16)38-26(33,34)24(28)29/h3-13,23-24,36H,2,14-15H2,1H3/t23-/m1/s1
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| InChIKey |
VHSPKQAESIGBIC-HSZRJFAPSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cholesteryl ester transfer protein (CETP) | Target Info | Inhibitor | [2], [3] |
| Panther Pathway | CCKR signaling map ST | |||
| Reactome | LDL-mediated lipid transport | |||
| HDL-mediated lipid transport | ||||
| WikiPathways | Statin Pathway | |||
| Lipid digestion, mobilization, and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025536) | |||
| REF 2 | Pfizer. Product Development Pipeline. March 31 2009. | |||
| REF 3 | Flavonoids as inhibitors of MRP1-like efflux activity in human erythrocytes. A structure-activity relationship study. Oncol Res. 2003;13(11):463-9. | |||
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