Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03JQR
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| Former ID |
DND000048
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| Drug Name |
RG-7273
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| Synonyms |
RG 7273; RG7273
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| Indication | Lipid metabolism disorder [ICD-11: 5C52.Z] | Discontinued in Phase 1 | [1] | |
| Company |
Hoffmann-La Roche
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ATP-binding cassette transporter A1 (ABCA1) | Target Info | Inducer | [2] |
| KEGG Pathway | ABC transporters | |||
| Fat digestion and absorption | ||||
| NetPath Pathway | Leptin Signaling Pathway | |||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | HDL-mediated lipid transport | |||
| PPARA activates gene expression | ||||
| WikiPathways | Statin Pathway | |||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Lipid digestion, mobilization, and transport | ||||
| SREBF and miR33 in cholesterol and lipid homeostasis | ||||
| Folate Metabolism | ||||
| Vitamin B12 Metabolism | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031594) | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 756). | |||
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