Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03JNC
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| Former ID |
DIB019895
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| Drug Name |
garcinol
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| Synonyms |
Garcinol; Camboginol; 78824-30-3; AC1Q1NUM; GTPL7001; QDKLRKZQSOQWJQ-SMDXAGPFSA-N; ZINC4098424; AKOS025142024; (1S,5R,7R)-3-[(3,4-dihydroxyphenyl)(hydroxy)methylidene]-6,6-dimethyl-1-[(2S)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl]-5,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]nonane-2,4,9-trione; (1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C38H50O6
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| Canonical SMILES |
CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C
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| InChI |
1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21H2,1-6,8-10H3/b32-31-/t27-,28+,37+,38-/m0/s1
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| InChIKey |
DTTONLKLWRTCAB-BZSUNBQASA-N
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| CAS Number |
CAS 78824-30-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:5276
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Bacteroides
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Bacteroides was increased by Garcinol (p < 0.05). | |||
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Studied Microbe: Parabacteroides
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Parabacteroides was increased by Garcinol (p < 0.05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Lachnospira
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Lachnospira was decreased by Garcinol (p < 0.05). | |||
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Studied Microbe: Lachnospiraceae bacterium NK4A136
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Lachnospiraceae_NK4A136 was decreased by Garcinol (p < 0.05). | |||
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Studied Microbe: Oscillibacter
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Oscillibacter was decreased by Garcinol (p < 0.05). | |||
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Studied Microbe: Ruminiclostridium
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Ruminiclostridium was decreased by Garcinol (p < 0.05). | |||
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Studied Microbe: Ruminococcus_1
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Ruminococcus_1 was decreased by Garcinol (p < 0.05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Akkermansia was increased by Garcinol (p < 0.05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
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Studied Microbe: Bacteroidetes
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Bacteroidetes was increased by Garcinol (p < 0.05). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7001). | |||
| REF 2 | Garcinol Reduces Obesity in High-Fat-Diet-Fed Mice by Modulating Gut Microbiota Composition. Mol Nutr Food Res. 2019 Jan;63(2):e1800390. | |||
| REF 3 | Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene e... J Biol Chem. 2004 Aug 6;279(32):33716-26. | |||
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