Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03HQE
|
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| Former ID |
DNC002394
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| Drug Name |
CRT0066101
|
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| Drug Type |
Small molecular drug
|
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
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| Formula |
C18H24Cl2N6O
|
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| Canonical SMILES |
CCC(CNC1=NC(=NC=C1)C2=C(C=CC(=C2)C3=CN(N=C3)C)O)N.Cl.Cl
|
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| InChI |
1S/C18H22N6O.2ClH/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13;;/h4-9,11,14,25H,3,10,19H2,1-2H3,(H,20,21,23);2*1H/t14-;;/m1../s1
|
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| InChIKey |
CXYCRYGNFKDPRH-FMOMHUKBSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Protein kinase D (PRKD1) | Target Info | Inhibitor | [2] |
| NetPath Pathway | FSH Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Panther Pathway | Angiogenesis | |||
| EGF receptor signaling pathway | ||||
| VEGF signaling pathway | ||||
| CCKR signaling map ST | ||||
| Pathway Interaction Database | LPA receptor mediated events | |||
| IGF1 pathway | ||||
| Reactome | Sphingolipid de novo biosynthesis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8048). | |||
| REF 2 | Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta. 2010 Dec;1806(2):183-92. | |||
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