Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03EZE
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| Former ID |
DNCL002429
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| Drug Name |
GSK2126458
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| Synonyms |
1086062-66-9; Omipalisib; GSK-2126458; GSK 2126458; UNII-1X8F5A3NA0; 2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide; 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide; 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide; 1X8F5A3NA0; Omipalisib (GSK2126458, GSK458); C25H17F2N5O3S; Omipalisib [USAN:INN]
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| Drug Type |
Small molecular drug
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| Indication | Lymphoma [ICD-11: 2A80-2A86; ICD-9: 202.8, 208.9] | Phase 1 | [1] | |
| Company |
GlaxoSmithKline
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H17F2N5O3S
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| Canonical SMILES |
COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
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| InChI |
1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3
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| InChIKey |
CGBJSGAELGCMKE-UHFFFAOYSA-N
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| CAS Number |
CAS 1086062-66-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
57273576, 85016178, 96021909, 104253094, 125329925, 125749354, 126661311, 126731330, 136340187, 136350051, 137275909, 141918282, 143499577, 152044074, 152234920, 152258166, 152344028, 160647003, 160778570, 162011414, 162037968, 162202629, 165246667, 170483104, 172650738, 172657970, 174526113, 185998816, 189622840, 198943133, 223378052, 223654388, 223705264, 224226328, 226924128, 242059765, 242560188, 245973244, 251963085, 251971092, 252160285, 252215507, 252451841, 252543397
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| ChEBI ID |
CHEBI:95093
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Dual PI3K/mTOR inhibitors, GSK2126458 and PKI-587, suppress tumor progression and increase radiosensitivity in nasopharyngeal carcinoma. Mol Cancer Ther. 2015 Feb;14(2):429-39. | |||
| REF 2 | Company report (GSK) | |||
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