Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02YIJ
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| Former ID |
DIB020083
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| Drug Name |
isocarbacyclin
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| Synonyms |
9-O-methanoprostaglandin I
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C21H34O4
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| Canonical SMILES |
CCCCCC(C=CC1C(CC2C1CC(=C2)CCCCC(=O)O)O)O
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| InChI |
1S/C21H34O4/c1-2-3-4-8-17(22)10-11-18-19-13-15(7-5-6-9-21(24)25)12-16(19)14-20(18)23/h10-12,16-20,22-23H,2-9,13-14H2,1H3,(H,24,25)/b11-10+/t16-,17-,18+,19-,20+/m0/s1
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| InChIKey |
JANVYOZZTKSZGN-WCAFQOMDSA-N
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| CAS Number |
CAS 88911-35-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostacyclin receptor (PTGIR) | Target Info | Agonist | [2] |
| Prostaglandin E2 receptor EP2 (PTGER2) | Target Info | Agonist | [2] | |
| Prostaglandin E2 receptor EP3 (PTGER3) | Target Info | Agonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Vascular smooth muscle contraction | ||||
| Platelet activation | ||||
| Calcium signaling pathway | ||||
| cAMP signaling pathway | ||||
| Regulation of lipolysis in adipocytes | ||||
| Pathways in cancer | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Renin secretion | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathwhiz Pathway | Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin | |||
| Pathway Interaction Database | Thromboxane A2 receptor signaling | |||
| Reactome | Prostanoid ligand receptors | |||
| G alpha (s) signalling events | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | ||||
| Endothelin Pathways | ||||
| Platelet homeostasis | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Ovarian Infertility Genes | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1934). | |||
| REF 2 | Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. | |||
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