Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02XLI
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| Former ID |
DIB003325
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| Drug Name |
LY-2979165
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| Synonyms |
Bipolar disorder therapy, Eli Lilly
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| Drug Type |
Small molecular drug
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| Indication | Bipolar disorder [ICD-11: 6A60; ICD-10: F31] | Phase 1 | [1] | |
| Company |
Eli Lilly & Co
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| Structure |
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Download2D MOL |
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| Formula |
C13H17N5O5S
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| Canonical SMILES |
CC(C(=O)NC1(CC(C2C1C2C(=O)O)SC3=NC=NN3)C(=O)O)N
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| InChI |
1S/C13H17N5O5S/c1-4(14)9(19)17-13(11(22)23)2-5(24-12-15-3-16-18-12)6-7(8(6)13)10(20)21/h3-8H,2,14H2,1H3,(H,17,19)(H,20,21)(H,22,23)(H,15,16,18)/t4-,5+,6-,7-,8-,13-/m0/s1
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| InChIKey |
BBGHHIUQOKQCBW-LDZWZCGGSA-N
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| CAS Number |
CAS 1311385-35-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 2 (mGluR2) | Target Info | Modulator | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glutamatergic synapse | ||||
| Cocaine addiction | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Ionotropic glutamate receptor pathway | ||||
| Metabotropic glutamate receptor group II pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01248052) A First Human Dose Study to Investigate Safety and Tolerability of LY2979165 in Healthy Volunteers in Eli Lilly and Company. | |||
| REF 2 | Annual Reports in Medicinal Chemistry. Volume 47, 2012, Page(78). | |||
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