Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02WAB
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| Former ID |
DIB006122
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| Drug Name |
Diloxanide
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| Synonyms |
Entamide; Diloxanid; Amebamida; Ame-boots; 579-38-4; 2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide; Diloxanidum [INN-Latin]; Diloxanida [INN-Spanish]; Acetamide, 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-; Diloxanide [INN:BAN:DCF]; UNII-89134SCM7M; RD 3803; B 4453; EINECS 209-439-4; C9H9Cl2NO2; BRN 2840273; 2,2-Dichloro-4'-hydroxy-N-methylacetanilide; 89134SCM7M; ACETANILIDE, 2,2-DICHLORO-4'-HYDROXY-N-METHYL-; Diloxanida; Diloxanidum; Diloxamide; Diloxanide (INN); 2,2-Dichlor-4'-hydroxy-N-methylacetanilid
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| Drug Type |
Small molecular drug
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| Indication | Parasitic infection [ICD-11: 1D0Y-1G2Z; ICD-10: B85-B89] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H9Cl2NO2
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| Canonical SMILES |
CN(C1=CC=C(C=C1)O)C(=O)C(Cl)Cl
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| InChI |
1S/C9H9Cl2NO2/c1-12(9(14)8(10)11)6-2-4-7(13)5-3-6/h2-5,8,13H,1H3
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| InChIKey |
GZZZSOOGQLOEOB-UHFFFAOYSA-N
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| CAS Number |
CAS 579-38-4
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| PubChem Compound ID | ||||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Ruminococcus bromii
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Diloxanide furoate (adjusted p-values: 9.08E-03). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
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