Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02VBF
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| Former ID |
DIB018012
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| Drug Name |
BI-D1870
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| Synonyms |
501437-28-1; 2-((3,5-difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one; 2-(3,5-difluoro-4-hydroxyanilino)-5,7-dimethyl-8-(3-methylbutyl)-7H-pteridin-6-one; C19H23F2N5O2; 2-(3,5-difluoro-4-hydroxyphenylamino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one; BI-D 1870; CHEMBL573107; GTPL8038; SCHEMBL13881333; CTK8I8998; BDBM25017; DTXSID40648506; BID1870; MolPort-008-266-821; HMS3244D11; HMS3244C12; HMS3244C11; BCPP000343; HMS3651D17; BCP01977; EX-A2471; NSC747342
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| Drug Type |
Small molecular drug
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| Indication | Chronic lymphocytic leukaemia [ICD-11: 2A82.0; ICD-10: C83.0, C91.1] | Preclinical | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C19H23F2N5O2
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| Canonical SMILES |
CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C
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| InChI |
1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)
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| InChIKey |
DTEKTGDVSARYDS-UHFFFAOYSA-N
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| CAS Number |
CAS 501437-28-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
56374161, 57539505, 58088277, 81043444, 103694291, 118847198, 123124574, 125362031, 126531503, 131408220, 135685188, 135685189, 135685208, 136368051, 144115704, 152058298, 152344438, 162009825, 162012025, 162201842, 163163891, 163620707, 163685623, 163686024, 170495491, 180371698, 184824669, 210024009, 223398086, 223671510, 238870382, 241103234, 242060180, 249565718, 252160224, 252214989, 252437834, 252543290
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ribosomal protein S6 kinase alpha-1 (RSK1) | Target Info | Inhibitor | [1] |
| Ribosomal protein S6 kinase alpha-2 (RSK2) | Target Info | Inhibitor | [1] | |
| Ribosomal protein S6 kinase alpha-3 (RSK3) | Target Info | Inhibitor | [1] | |
| Ribosomal protein S6 kinase alpha-6 (RSK6) | Target Info | Inhibitor | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401(1):29-38. | |||
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