Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D02UKX
|
|||
Former ID |
DIB015315
|
|||
Drug Name |
CAP1-6D
|
|||
Synonyms |
Modified CEA peptide (pancreatic cancer), University of Chicago
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Pancreatic cancer [ICD-11: 2C10] | Phase 2 | [1] | |
Company |
University of Chicago
|
|||
Structure |
Download2D MOL |
|||
Formula |
C43H68N10O15
|
|||
Canonical SMILES |
CC(C)CC(C(=O)NC(CO)C(=O)NCC(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)N
|
|||
InChI |
1S/C43H68N10O15/c1-20(2)12-27(49-37(61)26(44)15-24-8-10-25(55)11-9-24)40(64)53-32(19-54)38(62)46-18-34(57)47-23(7)36(60)48-30(17-35(58)59)42(66)50-28(13-21(3)4)39(63)51-29(16-33(45)56)41(65)52-31(43(67)68)14-22(5)6/h8-11,20-23,26-32,54-55H,12-19,44H2,1-7H3,(H2,45,56)(H,46,62)(H,47,57)(H,48,60)(H,49,61)(H,50,66)(H,51,63)(H,52,65)(H,53,64)(H,58,59)(H,67,68)
|
|||
InChIKey |
SNKUSVNHTCUELQ-UHFFFAOYSA-N
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Carcinoembryonic antigen CEA (CD66e) | Target Info | Modulator | [2], [3] |
NetPath Pathway | TGF_beta_Receptor Signaling Pathway |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT00203892) Study of CAP1-6D in Patients With Locally Advanced or Surgically Resected Pancreatic Adenocarcinoma. U.S. National Institutes of Health. | |||
REF 2 | Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen. Cancer Res. 1997 Oct 15;57(20):4570-7. | |||
REF 3 | HLA-A*0201-restricted CEA-derived peptide CAP1 is not a suitable target for T-cell-based immunotherapy. J Immunother. 2010 May;33(4):402-13. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.