Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D02RRY
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| Former ID |
DIB018969
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| Drug Name |
BI6015
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| Synonyms |
BI 6015; BI-6015
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C15H13N3O4S
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| Canonical SMILES |
CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N2C(=NC3=CC=CC=C32)C
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| InChI |
1S/C15H13N3O4S/c1-10-7-8-12(18(19)20)9-15(10)23(21,22)17-11(2)16-13-5-3-4-6-14(13)17/h3-9H,1-2H3
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| InChIKey |
ILVCPQPMRPHZSG-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hepatocyte nuclear factor 4-alpha (HNF4A) | Target Info | Antagonist | [2] |
| KEGG Pathway | AMPK signaling pathway | |||
| Maturity onset diabetes of the young | ||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
| FOXA2 and FOXA3 transcription factor networks | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | Mesodermal Commitment Pathway | |||
| Integrated Pancreatic Cancer Pathway | ||||
| Nuclear Receptors | ||||
| AMPK Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6695). | |||
| REF 2 | HNF4alpha antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19(7):806-18. | |||
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