Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02QWB
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| Former ID |
DNC009298
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| Drug Name |
[2-(Imidazol-1-yl)ethyl]-bisphosphonic acid
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| Synonyms |
CHEMBL446734; 1-deshydroxyzoledronate; [2-(Imidazol-1-yl)ethyl]-bisphosphonic acid; SCHEMBL515542; FBSQLNMIJFINOJ-UHFFFAOYSA-N; BDBM50273714; 2-(imidazol-1-yl)ethane-1,1-diphosphonic acid; 2-(1H-Imidazole-1-yl)ethylidenebisphosphonic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C5H10N2O6P2
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| Canonical SMILES |
C1=CN(C=N1)CC(P(=O)(O)O)P(=O)(O)O
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| InChI |
1S/C5H10N2O6P2/c8-14(9,10)5(15(11,12)13)3-7-2-1-6-4-7/h1-2,4-5H,3H2,(H2,8,9,10)(H2,11,12,13)
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| InChIKey |
FBSQLNMIJFINOJ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Geranyltranstransferase (FDPS) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
| Superpathway of cholesterol biosynthesis | ||||
| Trans, trans-farnesyl diphosphate biosynthesis | ||||
| Geranylgeranyldiphosphate biosynthesis | ||||
| KEGG Pathway | Terpenoid backbone biosynthesis | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Influenza A | ||||
| HTLV-I infection | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Cholesterol biosynthesis | |||
| Pathwhiz Pathway | Steroid Biosynthesis | |||
| Reactome | Cholesterol biosynthesis | |||
| Activation of gene expression by SREBF (SREBP) | ||||
| WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
| SREBP signalling | ||||
| Cholesterol Biosynthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocy... J Med Chem. 2008 Nov 13;51(21):6800-7. | |||
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